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Considering you have 400 users, have you made adjustments in your settings for optimum performance.. JVMMaxHeapSize= in the notes.ini (for Amgr's JVM) should be around 1024mb and http active threads should be around 600. Please review the following doc. http://www.ibm.com/developerworks/lotus/library/notes852-trav-perf/index.html
Feedback response number WEBB8K6MZ4 created by ~Vera Opnuzengon on 07/27/2011